Biochemistry II
Outline
Education:
The Department of Biochemistry II takes charge of the lectures and laboratories on biochemistry and molecular biology for the first- and second-year medical students.
91猎奇:
1. Molecular mechanisms of the regulation of vascular network formation.
2. Roles and molecular basis of neuro-vascular interactions.
3. Mechanisms of regulation of alternative pre-mRNA processing.
4. Mechanisms underlying stress-related diseases and identification of novel prophylactic agents.
5.Molecular mechanisms of development of eye diseases.
Please refer to references listed below.
e-mail: biochem2@kanazawa-med.ac.jp
Faculty
Professor
Associate Professor
Senior Assistant Professor
Assistant Professor
Professor Emeritus
91猎奇 Achievements
Ikeda T, Hong S, Yoshida S, Srivastava SP, Kunamneni A, Yao Y, Khuperkar O, Basrur V, Kuang H, Kachman M, Raskind A, Baum H, Joshi A, Swaroop V, Thurman A, Kopasz-GemmenO, Kandukuri S, Pradeepa FNU, Yonekura H, Lin JD, Inoki K.
HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis.
Cell Rep. 44(10):116382 (2025)
Yonekura H, Kato I, Yamamoto Y, Ikeda T, Higashida H, Okamoto H.
Biosynthesis and Function of VIP and Oxytocin: Mechanisms of C-terminal Amidation, Oxytocin Secretion and Transport.
Endocrinology 164(9):bqad121 (2023)
Saito-Takatsuji H, Yoshitomi Y, Yamamoto R, Furuyama T, Ishigaki Y, Kato N, Yonekura H, Ikeda T.
Transthyretin Is Commonly Upregulated in the Hippocampus of Two Stress-Induced Depression Mouse Models.
Int. J. Mol. Sci. 24(4):3736 (2023)
Ikeda T*, Yoshitake Y*, Yoshitomi Y, Saito-Takatsuji H, Ishigaki Y, Yonekura H. *equal contribution
EPAC2 acts as a negative regulator in Matrigel-driven tubulogenesis of human microvascular endothelial cells.
Sci Rep. 11(1):19453 (2021)
Yoshitomi Y, Ikeda T, Saito-Takatsuji H, Yonekura H.
Emerging role of AP-1 transcription factor JunB in angiogenesis and vascular development.
Int J Mol Sci. 22(6):2804 (2021)
External 91猎奇 Funding
JSPS KAKENHI Grant Number 24K02890 (Grant-in-Aid for Scientific 91猎奇 (B), Takayuki Ikeda, 2024～2027, The role of sVEGFR-1 in healthy life expectancy and its application to Extending Healthy Life Expectancy.)
JSPS KAKENHI Grant Number 24K10058 (Grant-in-Aid for Scientific 91猎奇 (C), Hideto Yonekura, 2024～2027, Molecular mechanisms of initiation and termination of vascular network formation.)
JSPS KAKENHI Grant Number 22K11789 (Grant-in-Sid for Scientific 91猎奇 (C), Hidehito Saito-Takatsuji, 2022～2025, The molecular mechanism of vascular protection and verification of treatment and prevention effects by collagen tripeptide.)
JSPS KAKENHI Grant Number 22K06905 (Grant-in-Sid for Scientific 91猎奇 (C), Yasuo Yoshitomi, 2022～2024, Molecular Mechanisms of Vascular Remodeling regulated by the Mechanosensor Piezo1-JunB Signaling.)
Takeda Science Foundation (Takayuki Ikeda, 2021, The role of E3 ubiquitin ligase HUWE1 for Rheb activation.)