General and Digestive Surgery
Outline
Main 91猎奇 Contents:
1. Elucidation of the molecular mechanisms by which dysregulated sphingolipid metabolism contributes to the carcinogenesis, progression, and metastasis of colorectal cancer.
2. Integrated genomic analysis of somatic mutations in tumor suppressor genes in colorectal cancer and exploration of their clinical applications.
3. Development of novel therapeutic strategies to improve clinical outcomes of chemotherapy for gastrointestinal cancers.
4. Evaluation of the efficacy of gut immune-enhancing therapies for gastrointestinal cancers and establishment of a new immunotherapeutic platform.
5. Validation of the safety and efficacy of robot-assisted surgery for gastrointestinal cancers and optimization of minimally invasive treatment approaches.
Main Clinical Fields:
Upper digestive surgery, Colorectal surgery, Hepatobiliary–pancreatic and splenic surgery, Abdominal hernia surgery, Abdominal malignant soft tissue tumor surgery, Obesity surgical treatment
e-mail: gastsurg@kanazawa-med.ac.jp
Faculty
Professor and Chair
Professor
Associate Professor
Associate Professor
Senior Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
91猎奇 Achievements
- Sannomiya Y, Sakamoto T, Hiramatsu Y, Ueshima M, Liu Y, Nishiki H, Hashimoto A, Tomita Y, Miyata T, Okamoto K, Shimasaki T, Fujita H, Yamada S, Takamura H. Accuracy of Automatic Quantitative Analysis of Pathological Tissue Images Using ChatGPT Data Analyst: Comparison with Semi-Automated Analysis in an MC38 Mouse Liver Metastasis Model. Microsc Res Tech. 2026. doi: 10.1002/jemt.70128.
- Nishiki H, Ura H, Togi S, Hatanaka H, Fujita H, Takamura H, Niida Y. Integrated Analysis of Somatic DNA Variants and DNA Methylation of Tumor Suppressor Genes in Colorectal Cancer. Int J Mol Sci. 2025; 26(4): 1642. doi: 10.3390/ijms26041642.
- Okamoto K, Takamura H, Nagayama T, Sannomiya Y, Hashimoto A, Nishiki H, Kaida D, Miyata T, Tsuji T, Fujita H, Kinami S, Ninomiya I, Inaki N. Usefulness of Perioperative Nutritional Therapy with the Glutamine/Arginine/Calcium β-Hydroxy-β-Methylbutyrate Product in Esophageal Cancer Surgery: A Single-Center Retrospective Study. Nutrients. 2024; 16(13): 2126. doi: 10.3390/nu16132126.
- Miyata T, Shinden Y, Motoyama S, Sannomiya Y, Tamezawa H, Nagayama T, Nishiki H, Hashimoto A, Kaida D, Fujita H, Ueda N, Takamura H. Non-Alcoholic Fatty Liver Disease May Be a Risk Factor for Liver Metastasis After Radical Surgery for Colorectal Cancer: A Retrospective Study. J Gastrointest Cancer. 55(2): 932-939, 2024.
- Kinami S, Kaida D, Okamoto K, Fujimura T, Iida Y, Inaki N, Takamura H. Long?term survival prognosis of function?preserving curative gastrectomy for early gastric cancer. Oncol Lett. 2024; 27(3): 115. doi: 10.3892/ol.2024.14248.
External 91猎奇 Funding
- TAKAMURA H. Grant-in-Aid for Scientific 91猎奇 of the Ministry of Education, Science and Culture 2022; Basic research for the application of selective sphingomyelin synthase 2 inhibitor to the liver surgery.
- MIYATA T. Grant-in-Aid for Scientific 91猎奇 of the Ministry of Education, Science and Culture 2021; 91猎奇 for new biomarkers of the sinusoid obstructive syndrome of liver focusing on platelet aggregation.
- TOMITA Y. Grant-in-Aid for Scientific 91猎奇 of the Ministry of Education, Science and Culture 2021; Suppression of colorectal cancer liver metastasis by inhibition of sphingomyelin synthase in fatty liver.
- NAKAMURA N. Grant-in-Aid for Scientific 91猎奇 of the Ministry of Education, Science and Culture 2021; 91猎奇 for the effects of sphingolipids on non-alcoholic fatty liver disease-related liver carcinogenesis.
- OKAMOTO K. Grant-in-Aid for Scientific 91猎奇 of the Ministry of Education, Science and Culture 2018; Fundamental studies on tumor regulation through cellular senescence of fibroblasts in the cancer microenvironment.