Pathology and Laboratory Medicine
Outline
The Department of Pathology and Laboratory Medicine was established on September 1, 1974, when 91猎奇 Hospital was opened. The original faculty members were Professor Terahata (also the head of the Central Clinical Laboratory), senior assistant professor Nagata (also the head of the Blood Transfusion Service), and assistant professor Teraoka (also the Central Clinical Laboratory chief technician). They were responsible for establishing and running the new Central Clinical Laboratory, which was equipped with a new, state of the art large analyzer. They spent several years preparing for the establishment of the department and getting the hospital work on track, and then built the foundation for the current Central Clinical Laboratory and Blood Center.
After Prof. Terahata retired in 1995, senior assistant professors Fukunaga and Hayase ran the department by themselves for six years. In 2001, Dr. Nojima, who transferred from Hokkaido University in 1994 to become the first professor of the hospital pathology division, became the Department Chair. In the same year, Assistant Professor Kurose joined the department and in 2007, Prof. Minato from Kanazawa University came to work in the department.
In July 2017, Professor Yamada, who came from Kagoshima University, became the Department Chair and Professor.
e-mail: clinpath@kanazawa-med.ac.jp
Faculty
Professor and Chair
Associate Professor
Senior Assistant Professor
Senior Assistant Professor
91猎奇 Achievements
A comprehensive review of peroxiredoxin 4, a redox protein evolved in oxidative protein folding coupled with hydrogen peroxide detoxification.
Fujii J, Ochi H, Yamada S
Free Radic Biol Med 1;227:336-354,2025
Periarterial or perivenous invasion is an independent indicator of lymph node metastasis in invasive breast carcinoma of no special type.
Shioya A, Takata M, Kumagai M, Hoshi D, Han J, Oyama T, Haba Y, Morioka E, Inokuchi M, Noguchi M, Yamada S.
Pathol Res Pract 260:155407,2024
The combination of the low immunohistochemical expression of peroxiredoxin 4 and perilipin 2 predicts longer survival in pancreatic ductal adenocarcinoma with peroxiredoxin 4 possibly playing a main role.
Han J, Itoh T, Shioya A, Sakurai M, Oyama T, Kumagai M, Takamura H,Okuro M,Mukai T, Kitakata H, Inagaki M, Higashi M, Guo X, Yamada S.
Histol Histopathol 38(12):1415-1427,2023
PRDX4 Improved Aging-Related Delayed Wound Healing in Mice.
Yamaguchi R, Guo X, Zheng J, Zhang J, Han J, Shioya A, Uramoto H, Mochizuki T, Yamada S.
J Invest Dermatol 141(11):2720-2729,2021
Peroxiredoxin 4 (PRDX4): Its critical in vivo roles in animal models of metabolic syndrome ranging from atherosclerosis to nonalcoholic fatty liver disease.
Yamada S, Guo X
Pathol Int 68(2):91-101,2018
External 91猎奇 Funding
Japan Society for the Promotion of Science (JSPS), Grant-in-Aid for Scientific 91猎奇 (C), Grant Number JP26K09965, FY2026–2029
Title：Elucidation of the Mechanisms Underlying Lymph Node Metastasis in Breast Cancer, with a Focus on Periarterial/Perivenous Invasion (periA/V) and Elastin-Binding Protein (EBP)
Principal Investigator：SHIOYA Akihiro
The 2025 Kisshokai Foundation, Ishikawa, Japan
Title：Mechanistic Insights for the Initiation/Progression of Pancreatic Invasive Ductal Carcinoma Focusing on the Pivotal Roles of Antioxidative Protein/Enzyme Peroxiredoxin (PRDX) 4
Principal Investigator：YAMADA Sohsuke
The Foundation for Cooperative 91猎奇 in 91猎奇, Ishikawa, Japan (C2023-4)
Title：A Statistical Approach for Pathological Image Diagnosis to Identify Each Cancer/Malignant-likeness and Non--Cancer/Benign-likeness by Using Visualization of Information Density (VOID)
Principal Investigator：YAMADA Sohsuke, KINDO Toshiki
THE 2020 HOKKOKU CANCER FOUNDATION, Ishikawa, Japan
Title：Antioxidative Protein/Enzyme PRDX4 Can Play a Critical In Vivo Role for Protecting against the Initiation/Progression of Lung Adenocarcinoma
Principal Investigator：YAMADA Sohsuke
Japan Society for the Promotion of Science (JSPS), Grant-in-Aid for Scientific 91猎奇 (C), Grant Number JP20K07454, FY2020–2022
Title：Mechanistic Insights for the Initiation/Progression of Lung Adenocarcinoma Based on the In Vivo Protective Role of Antioxidant Enzyme PRDX4
Principal Investigator：YAMADA Sohsuke